dbOGAP: Database of O-GlcNAcylated Proteins and Sites                                                                                

OGAP

Introduction: Protein O-GlcNAcylation is an O-linked glycosylation involving attachment of beta-N-acetylglucosamine (GlcNAc) to Ser/Thr residues catalyzed by O-GlcNAc transferase (OGT) without further extension of GlcNAc, whose removal is catalyzed by O-GlcNAcase (OGA). Unlike N-linked and mucin-type O-linked glycosylation, O-GlcNAcylation occurs primarily in nucleocytoplasmic proteins, and is often dynamic and reciprocal to phosphorylation at the same or adjacent Ser/Thr residues (often mutually inhibitory). Compared to phosphorylation, the amount of research on O-GlcNAcylation has been disproportionally small. Growing evidences now suggest that O-GlcNAcylation is common and has broad roles in physiology and diseases especially through its interplay with phosphorylation, e.g., regulation of insulin signaling and roles in diabetes and neurodegenerative diseases. To facilitate research on O-GlcNAcylated proteins, we developed a database of O-GlcNAcylated proteins and sites (dbOGAP) based on experimental data curated from literature as well as from collaborating labs. The database also provides additional sequence annotations and functional information integrated from databases such as UniProt, and pathway and disease databases. Review statistics for the current version of dbOGAP (v1.0). For more, please see USHUPO 2010 abstract, presentation and the paper Jinlian Wang, Manabu Torii, Hongfang Liu, Gerald W Hart and Zhang-Zhi Hu*.dbOGAP - An Integrated Bioinformatics Resource for Protein O-GlcNAcylation. BMC Bioinformatics 2011, 12:91 .


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Browse database by: Gene Names A-E F-I J-N O-R S-V W-Z | Organisms | Pathways | Download data sets | Statistics

OGlcNAcScan, a Support Vector Machine-based sequence prediction
program to predict protein O-GlcNAcylation sites [Demo | Help]:


Enter a protein UniProtAC e.g. P01106 or sequence in FASTA format

Download the O-GlcNAc sites data used to train the SVM model.

You can help annotate the dbOGAP database!

Annotate protein O-GlcNAcyaltion [Help]:


Protein name*  
Protein ID/AC  
Modified site  
PubMed ID*  
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The discovery of the reciprocal relationship between protein O-GlcNAcylation and phosphorylation represents a paradigm shift in studying the regulation of cell signaling. OGT and OGA interact closely with kinases, phosphatases and their respective substrates to form intricate networks of protein O-GlcNAcylation and phosphorylation in regulating cell signaling. Review references for more information.

 

Email address is not mandatory but desired for assuring the data quality

Browse the O-GlcNAcylation Literature
(~490 O-GlcNAcylation related citations in the database)


To submit O-GlcNAc proteomic or more detailed literature data to the database, please contact or directly send to: dbOGAP@gmail.com


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